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- Creador:
- Test, Nick
- Owner:
- nicholas.homenda@tufts.edu
- Fecha de Subida:
- 10/09/2025
- Fecha Modificada:
- 10/09/2025
-
- Creador:
- Test, Nick
- Owner:
- nicholas.homenda@tufts.edu
- Fecha de Subida:
- 10/08/2025
- Fecha Modificada:
- 10/08/2025
-
- Tema:
- Towers and Electric lines
- Creador:
- Cushman, Charles W., 1896-1972
- Owner:
- nicholas.homenda@tufts.edu
- Fecha de Subida:
- 09/15/2025
- Fecha Modificada:
- 09/15/2025
- Derechos:
- In Copyright - Educational Use Permitted
- Label:
-
- Tema:
- Hedges (Plants) and Oleander
- Creador:
- Cushman, Charles W., 1896-1972
- Owner:
- nicholas.homenda@tufts.edu
- Fecha de Subida:
- 09/15/2025
- Fecha Modificada:
- 09/15/2025
- Derechos:
- In Copyright - Educational Use Permitted
- Label:
-
- Tema:
- Bays (Bodies of water) and Piers & wharves
- Creador:
- Cushman, Charles W., 1896-1972
- Owner:
- nicholas.homenda@tufts.edu
- Fecha de Subida:
- 09/15/2025
- Fecha Modificada:
- 09/15/2025
- Derechos:
- In Copyright - Educational Use Permitted
- Label:
-
- Creador:
- Cushman, Charles W., 1896-1972
- Owner:
- nicholas.homenda@tufts.edu
- Fecha de Subida:
- 09/15/2025
- Fecha Modificada:
- 09/15/2025
- Derechos:
- In Copyright - Educational Use Permitted
- Label:
-
- Tema:
- Lakes & ponds and Sailboats
- Creador:
- Cushman, Charles W., 1896-1972
- Owner:
- nicholas.homenda@tufts.edu
- Fecha de Subida:
- 09/15/2025
- Fecha Modificada:
- 09/15/2025
- Derechos:
- In Copyright - Educational Use Permitted
- Label:
-
- Tema:
- Harbors and Reflections
- Creador:
- Cushman, Charles W., 1896-1972
- Owner:
- nicholas.homenda@tufts.edu
- Fecha de Subida:
- 09/15/2025
- Fecha Modificada:
- 09/15/2025
- Derechos:
- In Copyright - Educational Use Permitted
- Label:
-
- Descripción:
- Funding for open access publishing provided by the Tufts Faculty Research Awards Committee (FRAC)
- Creador:
- Munro Krull, Erin and Börgers, Christoph
- Owner:
- nicholas.homenda@tufts.edu
- Editor:
- Tufts University Tisch Library
- Fecha de Subida:
- 09/12/2025
- Fecha Modificada:
- 09/12/2025
- Fecha de Creacion:
- 2024
- Derechos:
- In Copyright - Educational Use Permitted
- Resource Type:
- Article
- Identificador:
- https://doi.org/10.3389/fams.2023.1186333
- Abstract:
- Gap junctions are channels in cell membranes allowing ions to pass directly between cells. They are found throughout the body, including heart myocytes, neurons, and astrocytes. In cardiac tissue and throughout the nervous system, an action potential (AP) in one cell can trigger APs in neighboring cells connected by gap junctions. It is known experimentally that there is an ideal gap junction conductance for AP propagation—lower or higher conductance can lead to propagation failure. We explain this phenomenon geometrically in branching networks by analyzing an idealized model that focuses exclusively on gap junction and AP-generating currents. As expected, the gap junction conductance must be high enough for AP propagation to occur. However, if the gap junction conductance is too high, then it dominates the cell's intrinsic firing conductance and disrupts AP generation. We also identify conditions for semi-active propagation, where cells in the network are not individually excitable but still propagate action potentials.
- Bibliographic Citation:
- Munro Krull, E., & Börgers, C. (2024). Why strengthening gap junctions may hinder action potential propagation. Frontiers in Applied Mathematics and Statistics, 9, 1186333. https://doi.org/10.3389/fams.2023.1186333
- Label:
-
- Creador:
- Medford Publishing Company
- Owner:
- nicholas.homenda@tufts.edu
- Fecha de Subida:
- 09/12/2025
- Fecha Modificada:
- 09/12/2025
- Resource Type:
- Book
- Label:
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