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清除筛选 2024

1. Why strengthening gap junctions may hinder action potential propagation

描述:
Funding for open access publishing provided by the Tufts Faculty Research Awards Committee (FRAC)
学科:
Gap junctions (Cell biology)
创造者:
Munro Krull, Erin and Börgers, Christoph
Depositor:
nicholas.homenda@tufts.edu
出版者:
Tufts University Tisch Library
日期上传:
09/12/2025
修改日期:
09/12/2025
创建日期:
2024
权:
In Copyright - Educational Use Permitted
执照:
Creative Commons BY Attribution 4.0 International
Resource Type:
Article
识别码:
https://doi.org/10.3389/fams.2023.1186333
Abstract:
Gap junctions are channels in cell membranes allowing ions to pass directly between cells. They are found throughout the body, including heart myocytes, neurons, and astrocytes. In cardiac tissue and throughout the nervous system, an action potential (AP) in one cell can trigger APs in neighboring cells connected by gap junctions. It is known experimentally that there is an ideal gap junction conductance for AP propagation—lower or higher conductance can lead to propagation failure. We explain this phenomenon geometrically in branching networks by analyzing an idealized model that focuses exclusively on gap junction and AP-generating currents. As expected, the gap junction conductance must be high enough for AP propagation to occur. However, if the gap junction conductance is too high, then it dominates the cell's intrinsic firing conductance and disrupts AP generation. We also identify conditions for semi-active propagation, where cells in the network are not individually excitable but still propagate action potentials.
Bibliographic Citation:
Munro Krull, E., & Börgers, C. (2024). Why strengthening gap junctions may hinder action potential propagation. Frontiers in Applied Mathematics and Statistics, 9, 1186333. https://doi.org/10.3389/fams.2023.1186333
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