Anzahl der Ergebnisse, die pro Seite angezeigt werden
Ergebnisse ansehen als:
Suchergebnisse
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- Subject:
- Lakes & ponds and Sailboats
- Creator:
- Cushman, Charles W., 1896-1972
- Depositor:
- nicholas.homenda@tufts.edu
- Datum hochgeladen:
- 09/15/2025
- Datum geändert:
- 09/15/2025
- Rights Statement:
- In Copyright - Educational Use Permitted
- Label:
-
- Subject:
- Harbors and Reflections
- Creator:
- Cushman, Charles W., 1896-1972
- Depositor:
- nicholas.homenda@tufts.edu
- Datum hochgeladen:
- 09/15/2025
- Datum geändert:
- 09/15/2025
- Rights Statement:
- In Copyright - Educational Use Permitted
- Label:
-
- Description:
- Funding for open access publishing provided by the Tufts Faculty Research Awards Committee (FRAC)
- Subject:
- Gap junctions (Cell biology)
- Creator:
- Munro Krull, Erin and Börgers, Christoph
- Depositor:
- nicholas.homenda@tufts.edu
- Publisher:
- Tufts University Tisch Library
- Datum hochgeladen:
- 09/12/2025
- Datum geändert:
- 09/12/2025
- Date Created:
- 2024
- Rights Statement:
- In Copyright - Educational Use Permitted
- Resource Type:
- Article
- Identifier:
- https://doi.org/10.3389/fams.2023.1186333
- Abstract:
- Gap junctions are channels in cell membranes allowing ions to pass directly between cells. They are found throughout the body, including heart myocytes, neurons, and astrocytes. In cardiac tissue and throughout the nervous system, an action potential (AP) in one cell can trigger APs in neighboring cells connected by gap junctions. It is known experimentally that there is an ideal gap junction conductance for AP propagation—lower or higher conductance can lead to propagation failure. We explain this phenomenon geometrically in branching networks by analyzing an idealized model that focuses exclusively on gap junction and AP-generating currents. As expected, the gap junction conductance must be high enough for AP propagation to occur. However, if the gap junction conductance is too high, then it dominates the cell's intrinsic firing conductance and disrupts AP generation. We also identify conditions for semi-active propagation, where cells in the network are not individually excitable but still propagate action potentials.
- Bibliographic Citation:
- Munro Krull, E., & Börgers, C. (2024). Why strengthening gap junctions may hinder action potential propagation. Frontiers in Applied Mathematics and Statistics, 9, 1186333. https://doi.org/10.3389/fams.2023.1186333
- Label:
-
- Creator:
- Medford Publishing Company
- Depositor:
- nicholas.homenda@tufts.edu
- Publisher:
- [Medford, Mass.] Medford mercury, 1905
- Datum hochgeladen:
- 09/12/2025
- Datum geändert:
- 09/12/2025
- Resource Type:
- Book
- Label:
-
- Description:
- This illustration is from Charles Knight's "London."
- Creator:
- Kirchner and Anelay, Henry
- Depositor:
- nicholas.homenda@tufts.edu
- Publisher:
- Tufts Archival Research Center
- Datum hochgeladen:
- 09/12/2025
- Datum geändert:
- 09/12/2025
- Resource Type:
- Image
- Label:
-
- Description:
- This illustration is from H. Barton Baker, "The Stories of the Streets of London."
- Subject:
- Street lights, Markets, People, and Streets
- Creator:
- Baker, H. Barton
- Depositor:
- nicholas.homenda@tufts.edu
- Publisher:
- Tufts Archival Research Center
- Datum hochgeladen:
- 09/12/2025
- Datum geändert:
- 09/12/2025
- Rights Statement:
- In Copyright - Educational Use Permitted
- Resource Type:
- Image
- Label:
-
- Description:
- This illustration is from G.E. Mitton and Herbert M. Marshall "The Scenery of London"
- Subject:
- Views, Buildings, People, Buildings (built works), and Water
- Creator:
- Marshall, Herbert M.
- Depositor:
- nicholas.homenda@tufts.edu
- Publisher:
- Tufts Archival Research Center
- Datum hochgeladen:
- 09/12/2025
- Datum geändert:
- 09/12/2025
- Resource Type:
- Image
- Label:
-
- Creator:
- Test, Nick
- Depositor:
- nicholas.homenda@tufts.edu
- Datum hochgeladen:
- 08/12/2025
- Datum geändert:
- 08/12/2025
- Rights Statement:
- No Known Copyright
-
- Creator:
- Test, Nick
- Depositor:
- nicholas.homenda@tufts.edu
- Datum hochgeladen:
- 08/12/2025
- Datum geändert:
- 08/12/2025
- Rights Statement:
- No Known Copyright
-
- Creator:
- Test, Nick
- Depositor:
- nicholas.homenda@tufts.edu
- Datum hochgeladen:
- 08/12/2025
- Datum geändert:
- 08/12/2025
- Rights Statement:
- No Known Copyright